https://www.ncbi.nlm.nih.gov/books/NBK441917/

In an all out effort to reduce prescription pain medication dispensing and usage, particularly opioid, the medical establishment is redirecting patients to over the counter, NSAIDS like Tylenol. After all, they have been around a long time, tried and true, and can even be used in pregnancy. A lot of well intended patients have thus assumed that Tylenol is always a safe bet and can be taken routinely at the maximum doses indicated on the back of the bottle.

The reality is more somber and more complex. The truth is that most people can have a low dose of Tylenol occasionally and not encounter any issues. But there is a real dark side to Tylenol and it can harm the liver surprisingly easily. As of right now, acetaminophen accounts for over half of liver failure cases in the US ( and self harm overdoses account for a small percentage of that half). Liver toxicity is cumulative, meaning that all substance you ingest at the same time will compound each other: other prescription medications, alcohol, over the counter medications and even some supplements.

As a consumer, you should not underestimate the potential toxicity of Tylenol and pursue non-pharmacological ways of pain management as well as genuine resolution of pain producing conditions